(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Base Information

Chemical Name:(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone
CAS No.:1445985-81-8
Molecular Formula:C₂₆H₃₂Cl₂N₄OS
Molecular Weight:519.538
Hs Code.:

Synonyms:(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

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Chemical Property of (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

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Technology Process of (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

There total 17 articles about (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1445985-80-7
(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

: 1445985-81-8
(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: With triethylsilane; water; trifluoroacetic anhydride; for 0.0833333h;

Reference yield:

: 1445985-47-6
tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate

: 1445985-81-8
(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 70 °C

3: trifluoroacetic acid; triethylsilane / water / 0.08 h

With hydrogenchloride; triethylsilane; potassium carbonate; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 1445985-81-8
(R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 70 °C

2: trifluoroacetic acid; triethylsilane / water / 0.08 h

With triethylsilane; potassium carbonate; trifluoroacetic acid; sodium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00308