ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

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Chemical Name:ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate
CAS No.:1582806-50-5
Molecular Formula:C₂₀H₂₁F₇N₂O₅
Molecular Weight:502.386
Hs Code.:

Synonyms:ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

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Chemical Property of ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

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Technology Process of ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

There total 4 articles about ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₅H₁₃F₇N₂O₃

: 1582806-50-5
ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1126/science.1249198

Reference yield:

: 1582806-46-9
(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1582806-50-5
ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; trifluoroacetic acid; silver carbonate; 3,4-dihydro-2,5-dimethyl-2H-pyrano<2,3-b>quinoline / toluene / 20 h / 100 °C

2: ethylenediamine / dichloromethane; ethanol / 3 h / 40 °C

3: dichloromethane / 1 h / 20 °C

With palladium diacetate; ethylenediamine; 3,4-dihydro-2,5-dimethyl-2H-pyrano<2,3-b>quinoline; silver carbonate; trifluoroacetic acid; In ethanol; dichloromethane; toluene;
DOI:10.1126/science.1249198

Reference yield:

: 1582806-49-2
ethyl 2-((4S)-5-oxo-4-phthalimido-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

: 1582806-50-5
ethyl 2-((4S)-4-((t-butoxycarbonyl)amino)-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ethylenediamine / dichloromethane; ethanol / 3 h / 40 °C

2: dichloromethane / 1 h / 20 °C

With ethylenediamine; In ethanol; dichloromethane;
DOI:10.1126/science.1249198