ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

Base Information

Chemical Name:ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate
CAS No.:1582806-54-9
Molecular Formula:C₂₀H₂₃F₇N₂O₅
Molecular Weight:504.402
Hs Code.:

Synonyms:ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

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Chemical Property of ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

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Technology Process of ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

There total 8 articles about ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: ethyl (S,E)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hex-2-enoate

: 1582806-54-9
ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 24h; under 760.051 Torr;

Reference yield: 95.0%

: C₂₀H₂₁F₇N₂O₅

: 1582806-54-9
ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃;
DOI:10.1126/science.1249198

Reference yield:

: 1582806-49-2
ethyl 2-((4S)-5-oxo-4-phthalimido-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate

: 1582806-54-9
ethyl (S)-5-((t-butoxycarbonyl)amino)-6-oxo-6-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: ethylenediamine / dichloromethane; ethanol / 3 h / 40 °C

2: dichloromethane / 1 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C

4: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C

With palladium on activated charcoal; hydrogen; ethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1126/science.1249198