4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione

Base Information

• Chemical Name: 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione
• CAS No.: 1262307-31-2
• Molecular Formula: C₁₆H₁₈N₂O₅
• Molecular Weight: 318.329

Synonyms:4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione

Chemical Property of 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione

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Technology Process of 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione

There total 3 articles about 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1R,3R/S,9aS)-1-hydroxymethyl-8-(4-methoxy-benzyl)-3-methoxy-hexahydro-pyrazino[2,1-c][1,4]oxazine-6,9-dione (1262307-27-6) → 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione (1262307-31-2)

Guidance literature:

With silica gel; In dichloromethane; toluene; for 0.5h; Molecular sieve; Reflux;

DOI:10.1039/c0ob00357c

Reference yield:

C9H12BrNO5 (1073249-48-5) → 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione (1262307-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 0.33 h / 100 °C / Microwave irradiation

2: silica gel / dichloromethane; toluene / 0.5 h / Molecular sieve; Reflux

With silica gel; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1039/c0ob00357c

Reference yield:

4-methoxy-benzylamine (2393-23-9) → 4-(4-methoxy-benzyl)-10,12-dioxa-4,7-diaza-tricyclo[7.2.1.02,7]dodecane-3,6-dione (1262307-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 0.33 h / 100 °C / Microwave irradiation

2: silica gel / dichloromethane; toluene / 0.5 h / Molecular sieve; Reflux

With silica gel; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1039/c0ob00357c

upstream raw materials:

(1R,3R/S,9aS)-1-hydroxymethyl-8-(4-methoxy-benzyl)-3-methoxy-hexahydro-pyrazino[2,1-c][1,4]oxazine-6,9-dione

C₉H₁₂BrNO₅

4-methoxy-benzylamine

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