5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

Base Information

Chemical Name:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid
CAS No.:1093631-51-6
Molecular Formula:C₂₇H₂₀Cl₂N₂O₄S
Molecular Weight:539.439
Hs Code.:

Synonyms:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

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Chemical Property of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

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Technology Process of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

There total 6 articles about 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₄Cl₂N₂O₄S

: 1093631-51-6
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

Guidance literature:: C₂₉H₂₄Cl₂N₂O₄S; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 65977-55-1
5-Chlorothieno[3,2-b]pyridine

: 1093631-51-6
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 70 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: boron trichloride / dichloromethane / 0.08 h / -20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

5.1: water; sodium hydroxide / tetrahydrofuran; ethanol / 5 h / 60 °C

With n-butyllithium; water; boron trichloride; sodium carbonate; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 278597-30-1
[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol

: 1093631-51-6
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 2 h / 20 - 28 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 5 h / 60 °C

With 1,2,3-Benzotriazole; thionyl chloride; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;