N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Base Information

Chemical Name:N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide
CAS No.:1207965-13-6
Molecular Formula:C₂₆H₂₂F₃NO₂S
Molecular Weight:469.527
Hs Code.:

Synonyms:N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

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Chemical Property of N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

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Technology Process of N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

There total 8 articles about N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1207970-84-0
ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate

: 109-85-3
2-methoxyethylamine

: 1207965-13-6
N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Guidance literature:: ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

2-methoxyethylamine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h;

Reference yield: 90.0%

: 1613391-10-8
C₂₃H₁₅F₃O₂S

: 109-85-3
2-methoxyethylamine

: 1207965-13-6
N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jm5002919

Reference yield:

: 1171926-64-9
(7-bromo-1-benzothiophen-2-yl)methanol

: 1207965-13-6
N-(2-methoxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / Reflux; Inert atmosphere

2: phosphorus tribromide / diethyl ether / 2 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 14 h / 85 °C / Inert atmosphere

4: sodium hydroxide / methanol; ethanol; tetrahydrofuran / 0.5 h / 60 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1021/jm5002919