2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

Base Information

Chemical Name:2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol
CAS No.:286436-48-4
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

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Chemical Property of 2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

Chemical Property:

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Technology Process of 2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

There total 6 articles about 2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 286436-47-3
2-benzyloxycarbonyl-3,3-dimethyl-1,2-butandiol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 286436-48-4
2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1021/ja000763m

Reference yield:

: 286436-46-2
2-benzyloxycarbonyl-3,3-dimethyl-1-butene

: 286436-48-4
2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / OsO₄; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 24 h / 20 °C

2: 98 percent / imidazole / dimethylformamide / 40 °C

With 1H-imidazole; osmium(VIII) oxide; N-methyl-2-indolinone; In water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 1: Oxidation / 2: silylation;
DOI:10.1021/ja000763m

Reference yield:

: 2-benzyloxycarbonyl-1-chloro-3-methyl-1-butene

: 286436-48-4
2-benzyloxycarbonyl-1-(tert-butyldimethylsiloxy)-3,3-dimethyl-2-butanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuBr*Me₂S / tetrahydrofuran; diethyl ether / -78 - 0 °C

1.2: ZnCl₂ / diethyl ether; tetrahydrofuran / 0.25 h / -78 °C

1.3: 100 percent / diethyl ether; tetrahydrofuran / -78 - 20 °C

2.1: 91 percent / OsO₄; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 24 h / 20 °C

3.1: 98 percent / imidazole / dimethylformamide / 40 °C

With 1H-imidazole; osmium(VIII) oxide; N-methyl-2-indolinone; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 1.1: complexation / 1.2: complexation / 1.3: Methylation / 2.1: Oxidation / 3.1: silylation;
DOI:10.1021/ja000763m