3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

Base Information

Chemical Name:3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine
CAS No.:136544-43-9
Molecular Formula:C₁₈H₂₀N₂O₄
Molecular Weight:328.368
Hs Code.:

Synonyms:3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

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Chemical Property of 3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

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Technology Process of 3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

There total 6 articles about 3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136544-99-5
3,4-dihydro-2,2-dimethyl-6-nitro-3-oxo-4-phenacyl-2H-1,4-benzoxazine

: 136544-43-9
3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

Guidance literature:: With hydrogenchloride; methanol; borane; Multistep reaction;
DOI:10.1248/cpb.44.103

Reference yield:

: 85160-84-5
3,4-dihydro-2,2-dimethyl-6-nitro-3-oxo-2H-1,4-benzoxazine

: 136544-43-9
3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, RT, 2 h

2: 1.) BH₃, 2.) methanol, 3.) conc. HCl

With hydrogenchloride; methanol; borane; sodium hydride;
DOI:10.1248/cpb.44.103

Reference yield:

: 453560-91-3
2-bromo-N-(2-hydroxy-5-nitro-phenyl)-2-methyl-propionamide

: 136544-43-9
3,4-dihydro-4-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-6-nitro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / potassium carbonate / dimethylformamide / 50 °C

2: 1.) NaH / 1.) THF, 30 min, 2.) THF, RT, 2 h

3: 1.) BH₃, 2.) methanol, 3.) conc. HCl

With hydrogenchloride; methanol; borane; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.103