(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

Base Information

Chemical Name:(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide
CAS No.:216863-17-1
Molecular Formula:C₂₇H₃₂NO₂PS
Molecular Weight:465.596
Hs Code.:

Synonyms:(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

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Technology Process of (S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

There total 1 articles about (S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 112245-13-3
(S)-tert-leucinol

: 192371-81-6
3-(Diphenyl-phosphinothioyl)-3-phenyl-propionic acid

: 216863-16-0
(R)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

: 216863-17-1
(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile; for 48h; Ambient temperature;
DOI:10.1021/jo981420y

Reference yield: 74.0%

: 216863-17-1
(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

: 216862-96-3
(5S,2'S)-4,5-dihydro-2-(2'-(diphenylphosphinothioyl)-2'-phenylethyl)-5-tert-butyl-1,3-oxazole

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; for 1h; Heating; other reagent: triethylamine/mesyl chloride;
DOI:10.1021/jo981420y

Reference yield:

: 216863-17-1
(S)-3-(Diphenyl-phosphinothioyl)-N-((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-3-phenyl-propionamide

: (S)-4-tert-Butyl-2-((S)-2-diphenylphosphanyl-2-phenyl-ethyl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / CH₃O₂CNSO₂N(C₂H₅)3 / tetrahydrofuran / 1 h / Heating; other reagent: triethylamine/mesyl chloride

2: Raney nickel / methanol / 8 h / Ambient temperature

With Burgess Reagent; nickel; In tetrahydrofuran; methanol;
DOI:10.1021/jo981420y