(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Base Information

Chemical Name:(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid
CAS No.:638214-91-2
Molecular Formula:C₂₈H₂₈F₃NO₃
Molecular Weight:483.53
Hs Code.:

Synonyms:(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

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Chemical Property of (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

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Technology Process of (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

There total 12 articles about (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-87-6
ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

: 638214-91-2
(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Guidance literature:: ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate; With sodium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In methanol;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638214-91-2
(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

3: sodium hydroxide / methanol / 20 °C

With sodium hydroxide; tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 1: Suzuki Coupling / 2: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638214-91-2
(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

6.1: sodium hydroxide / methanol / 20 °C

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;