(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Base Information

• Chemical Name: (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid
• CAS No.: 638214-91-2
• Molecular Formula: C₂₈H₂₈F₃NO₃
• Molecular Weight: 483.53
• Mol file: 638214-91-2.mol

Synonyms:(2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Chemical Property of (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid

There total 12 articles about (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate (638214-87-6) → (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid (638214-91-2)

Guidance literature:

ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate; With sodium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In methanol;

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid (638214-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

3: sodium hydroxide / methanol / 20 °C

With sodium hydroxide; tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 1: Suzuki Coupling / 2: Mitsunobu reaction;

Reference yield:

2,6-Dibromopyridine (626-05-1) → (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoic acid (638214-91-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

6.1: sodium hydroxide / methanol / 20 °C

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;

upstream raw materials:

ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

2,6-Dibromopyridine

6-bromo-pyridine-2-carboxylic acid

ethyl (2E)-3-(4-hydroxy-3,5-dimethylphenyl)2-propenoate

Downstream raw materials:

3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propanoic acid