ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

Base Information

Chemical Name:ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate
CAS No.:638214-87-6
Molecular Formula:C₃₀H₃₂F₃NO₃
Molecular Weight:511.584
Hs Code.:

Synonyms:ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

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Chemical Property of ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

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Technology Process of ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

There total 12 articles about ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540778-59-4
ethyl (2E)-3-(4-hydroxy-3,5-dimethylphenyl)2-propenoate

: 638214-09-2
1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol

: 638214-87-6
ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 66h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638214-87-6
ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

With tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Suzuki Coupling / 2: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638214-87-6
ethyl (2E)-3-{3,5-dimethyl-4-[(1-{6-[4-(trifluoromethyl) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 66 h / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; tributylphosphine; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;