C₂₅H₃₁N₅O₄

Base Information

• Chemical Name: C₂₅H₃₁N₅O₄
• CAS No.: 1373496-80-0
• Molecular Formula: C₂₅H₃₁N₅O₄
• Molecular Weight: 465.552
• Mol file: 1373496-80-0.mol

Synonyms:C₂₅H₃₁N₅O₄

Chemical Property of C₂₅H₃₁N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₁N₅O₄

There total 7 articles about C₂₅H₃₁N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C11H14N4O2 (1373496-71-9) + C14H17NO2 (1373496-70-8) → C25H31N5O4 (1373496-80-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo300063u

Reference yield:

ethyl 2-(2-ethynylphenoxy)acetate (1373496-67-3) → C25H31N5O4 (1373496-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

1.2: pH 4

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / tetrahydrofuran; methanol; water / 12 h / 20 °C / Inert atmosphere

With dmap; copper(ll) sulfate pentahydrate; lithium hydroxide monohydrate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jo300063u

Reference yield:

2-Iodophenol (533-58-4) → C25H31N5O4 (1373496-80-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

4.2: pH 4

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Inert atmosphere

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / tetrahydrofuran; methanol; water / 12 h / 20 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; potassium carbonate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300063u

upstream raw materials:

C₁₁H₁₄N₄O₂

C₁₄H₁₇NO₂

ethyl (2-((trimethylsilyl)ethynyl)phenoxy)acetate

ethyl 2-(2-ethynylphenoxy)acetate