ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

Base Information

Chemical Name:ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate
CAS No.:1166828-15-4
Molecular Formula:C₂₄H₂₉N₃O₃
Molecular Weight:407.513
Hs Code.:

Synonyms:ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

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Chemical Property of ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

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Technology Process of ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

There total 7 articles about ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1166828-19-8
6-chloro-3,5-dimethylpyrazine-2-carboxamide

: 1166828-16-5
ethyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

: 1166828-15-4
ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm301296t

Reference yield:

: 1166827-50-4
ethyl 2-{[N-(tert-butoxycarbonyl)-L-alanyl]amino}-3-oxobutanoate

: 1166828-15-4
ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Reflux

2: trichlorophosphate / 0.17 h / 150 °C / Microwave irradiation

3: ammonia / methanol / 20 h / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane; ethanol / 2 h / 80 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; trifluoroacetic acid; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm301296t

Reference yield:

: 1166827-49-1
ethyl 3,5-dimethyl-6-oxo-1,6-dihydropyrazine-2-carboxylate

: 1166828-15-4
ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 0.17 h / 150 °C / Microwave irradiation

2: ammonia / methanol / 20 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane; ethanol / 2 h / 80 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water;
DOI:10.1021/jm301296t