4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

Base Information

Chemical Name:4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid
CAS No.:1166828-14-3
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

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Chemical Property of 4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

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Technology Process of 4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

There total 8 articles about 4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1166828-15-4
ethyl 4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]bicyclo[2.2.2]octane-1-carboxylate

: 1166828-14-3
4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: With potassium hydroxide; In tert-butyl alcohol; at 40 - 45 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm301296t

Reference yield:

: 1166827-50-4
ethyl 2-{[N-(tert-butoxycarbonyl)-L-alanyl]amino}-3-oxobutanoate

: 1166828-14-3
4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Reflux

2: trichlorophosphate / 0.17 h / 150 °C / Microwave irradiation

3: ammonia / methanol / 20 h / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane; ethanol / 2 h / 80 °C / Inert atmosphere

5: potassium hydroxide / tert-butyl alcohol / 1 h / 40 - 45 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; trifluoroacetic acid; potassium hydroxide; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water; 1,2-dichloro-ethane; tert-butyl alcohol;
DOI:10.1021/jm301296t

Reference yield:

: 1166827-49-1
ethyl 3,5-dimethyl-6-oxo-1,6-dihydropyrazine-2-carboxylate

: 1166828-14-3
4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 0.17 h / 150 °C / Microwave irradiation

2: ammonia / methanol / 20 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane; ethanol / 2 h / 80 °C / Inert atmosphere

4: potassium hydroxide / tert-butyl alcohol / 1 h / 40 - 45 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; potassium hydroxide; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jm301296t