N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

Base Information

Chemical Name:N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine
CAS No.:745795-97-5
Molecular Formula:C₆₅H₅₇N₃O₇
Molecular Weight:992.183
Hs Code.:

N-{N<sup>α</sup>,N<sup>ε</sup>-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

Synonyms:N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

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Chemical Property of N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

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Technology Process of N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

There total 5 articles about N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 745795-96-4
N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

: 745795-97-5
N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja049061d

Reference yield:

: 19694-02-1
Pyrene-1-carboxylic acid

: 745795-97-5
N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / PyBOP; ethyldiisopropylamine / dimethylformamide / 1 h / 20 °C

2: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja049061d

Reference yield:

: 516462-74-1
O-(4,4'-dimethoxytrityl)diethanolamine

: 745795-97-5
N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 80 percent / PyBOP; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

3: 77 percent / piperidine / dimethylformamide / 0.02 h / 20 °C

4: 72 percent / PyBOP; ethyldiisopropylamine / dimethylformamide / 1 h / 20 °C

5: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With piperidine; 1H-imidazole; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja049061d