516462-74-1Relevant articles and documents
Modified oligonucleotides and compound that can be used for synthesizing same
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Paragraph 0129-0130; 0131-0132, (2020/12/08)
The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.
Synthesis of triple helix forming oligonucleotides with a phenanthroline moiety into the 3′-3′ inversion site of polarity
Esposito, Veronica,Galeone, Aldo,Mayol, Luciano,Oliviero, Giorgia,Randazzo, Antonio,Varra, Michela
, p. 4228 - 4233 (2007/10/03)
A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3′-3′ inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002.