1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester

Base Information

• Chemical Name: 1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester
• CAS No.: 1009816-33-4
• Molecular Formula: C₃₁H₃₃F₂N₅O₅
• Molecular Weight: 593.63

Synonyms:1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester

Chemical Property of 1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester

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Technology Process of 1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester

There total 1 articles about 1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

Methyl-(1-methyl-[4]piperidyl)-amin (73579-08-5) + Benzyl 1-({[4-([2-[(phenoxycarbonyl)amino]pyridin-4-yl}oxy)-2,5-difluorophenyl]amino}carbonyl)cyclopropanecarboxylate (1009816-25-4) → 1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester (1009816-33-4)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield: 95.0%

1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester (1009816-33-4) → 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid (1009816-35-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 3.5h;

upstream raw materials:

Methyl-(1-methyl-[4]piperidyl)-amin

Benzyl 1-({[4-([2-[(phenoxycarbonyl)amino]pyridin-4-yl}oxy)-2,5-difluorophenyl]amino}carbonyl)cyclopropanecarboxylate

Downstream raw materials:

1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid

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