1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid
• CAS No.: 1009816-35-6
• Molecular Formula: C₂₄H₂₇F₂N₅O₅
• Molecular Weight: 503.506

Synonyms:1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid

Chemical Property of 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid

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Technology Process of 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid

There total 1 articles about 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester (1009816-33-4) → 1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid (1009816-35-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 3.5h;

Reference yield: 71.0%

1-(2,5-Difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid (1009816-35-6) + 4-fluoroaniline (371-40-4) → N-(2,5-difluoro-4-{[2-({[methyl(1-methylpiperidin-4-yl)amino]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃; for 15h;

upstream raw materials:

1-(2,5-difluoro-4-{2-[3-methyl-3-(1-methyl-piperidin-4-yl)-ureido]-pyridin-4-yloxy}-phenylcarbamoyl)-cyclopropanecarboxylic acid benzyl ester

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