methyl (RS)-4--3-(4-chlorophenyl)butanoate

Base Information

• Chemical Name: methyl (RS)-4--3-(4-chlorophenyl)butanoate
• CAS No.: 229182-23-4
• Molecular Formula: C₁₆H₂₂ClNO₄
• Molecular Weight: 327.808

Synonyms:methyl (RS)-4--3-(4-chlorophenyl)butanoate

Chemical Property of methyl (RS)-4--3-(4-chlorophenyl)butanoate

Chemical Property:

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Technology Process of methyl (RS)-4--3-(4-chlorophenyl)butanoate

There total 2 articles about methyl (RS)-4--3-(4-chlorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl (RS)-4-amino-3-(4-chlorophenyl)butanoate hydrochloride → methyl (RS)-4--3-(4-chlorophenyl)butanoate (229182-23-4)

Guidance literature:

With triethylamine; In ethanol; a) 0 deg C, 1.5 h, b) 25 deg C, 30 min;

DOI:10.1021/jm990076+

Reference yield:

4-amino-3-(4-chlorophenyl)butanoic acid (1134-47-0) → methyl (RS)-4--3-(4-chlorophenyl)butanoate (229182-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / HCl

2: 76 percent / Et₃N / ethanol / a) 0 deg C, 1.5 h, b) 25 deg C, 30 min

With hydrogenchloride; triethylamine; In ethanol;

DOI:10.1021/jm990076+

Reference yield: 78.0%

methyl (RS)-4--3-(4-chlorophenyl)butanoate (229182-23-4) → (RS)-4--3-(4-chlorophenyl)butanol (229182-24-5)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; dichloromethane; at -30 - 0 ℃; for 1.5h;

DOI:10.1021/jm990076+

upstream raw materials:

di-tert-butyl dicarbonate

4-amino-3-(4-chlorophenyl)butanoic acid

Downstream raw materials:

(RS)-4--3-(4-chlorophenyl)butanol

(RS)-5-(4-chlorophenyl)-2-piperidone

(RS)-4--3-(4-chlorophenyl)butanenitrile

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