2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346447-90-2
Molecular Formula:C₂₂H₂₁ClN₆O₂
Molecular Weight:436.901
Hs Code.:

Synonyms:2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Chemical Property:

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Technology Process of 2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

There total 8 articles about 2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1346447-89-9
2-((2-((3-(aminomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1346447-90-2
2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 1346447-90-2
2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 6 h / 80 °C

4: trifluoroacetic acid / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; ethanol; dichloromethane; water; iso-butanol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346447-90-2
2-((2-((3-(acrylamidomethyl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 0.33 h

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 6 h / 80 °C

4: trifluoroacetic acid / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; iso-butanol;