(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

Base Information

Chemical Name:(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide
CAS No.:1300748-99-5
Molecular Formula:C₂₉H₃₃N₇O₅S₂
Molecular Weight:623.757
Hs Code.:

Synonyms:(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

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Chemical Property of (E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

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Technology Process of (E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

There total 9 articles about (E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1300749-25-0
N-benzhydryl-N-((2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl) amine

: 610768-51-9
(2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)propenoic acid

: 1300748-99-5
(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00657b

Reference yield:

: 220378-46-1
methyl 3-(1-(N,N-dimethylsulfamoyl)imidazol-4-yl)-2-propenoate

: 1300748-99-5
(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

Guidance literature:: Multi-step reaction with 7 steps

1: diisobutylaluminium hydride

2: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

5: ethanol / 20 °C / Inert atmosphere

6: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C / Inert atmosphere

7: dmap; dicyclohexyl-carbodiimide / dichloromethane / -78 - 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; thionyl chloride; diisobutylaluminium hydride; hydrazine hydrate; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00657b

Reference yield:

: 220378-49-4
C₈H₁₃N₃O₃S

: 1300748-99-5
(E,E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-[3-(1-dimethyl-sulfamoyl-1H-imidazol-4-yl)-2-propenyl]-2-propenamide

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

4: ethanol / 20 °C / Inert atmosphere

5: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C / Inert atmosphere

6: dmap; dicyclohexyl-carbodiimide / dichloromethane / -78 - 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; thionyl chloride; hydrazine hydrate; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00657b