methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate

Base Information

• Chemical Name: methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate
• CAS No.: 162007-19-4
• Molecular Formula: C₂₉H₃₃N₇O₇S
• Molecular Weight: 623.69

Synonyms:methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate

Chemical Property of methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate

There total 4 articles about methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

5-amino-2-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanoic acid methyl ester + 2-methoxycarbonylbenzenesulfonyl chloride (26638-43-7) → methyl Nα-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-Nδ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate (162007-19-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1248/cpb.48.1270

Reference yield:

methyl Nδ-(tert-butoxycarbonyl)-L-ornithinate (51186-41-5) → methyl Nα-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-Nδ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate (162007-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Et₃N; DEPC / dimethylformamide / 1 h / 20 °C

2: HCl / ethyl acetate / 0.33 h / 20 °C

3: 55 percent / Et₃N / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; diethyl dicarbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.48.1270

Reference yield:

4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid (149010-53-7) → methyl Nα-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-Nδ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate (162007-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Et₃N; DEPC / dimethylformamide / 1 h / 20 °C

2: HCl / ethyl acetate / 0.33 h / 20 °C

3: 55 percent / Et₃N / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; diethyl dicarbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.48.1270

upstream raw materials:

2-methoxycarbonylbenzenesulfonyl chloride

methyl N^δ-(tert-butoxycarbonyl)-L-ornithinate

4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

methyl N^δ-(tert-butoxycarbonyl)-N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-ornithinate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 162007-19-4 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send