ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

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Chemical Name:ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate
CAS No.:1444001-41-5
Molecular Formula:C₂₇H₃₃N₅O₈S
Molecular Weight:587.654
Hs Code.:

Synonyms:ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

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Chemical Property of ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

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Technology Process of ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

There total 8 articles about ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1444001-36-8
ethyl 1-(4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

: 302964-20-1
2-tert-butoxycarbonylamino-1,3-thiazole-5-carboxylic acid chloride

: 1444001-41-5
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1444001-41-5
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / dimethyl sulfoxide / 15 h / 55 °C

2: N-benzyl-N,N,N-triethylammonium chloride; potassium permanganate / dichloromethane / 84 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr

4: ethanol / 15 h / Reflux

5: dmap / tetrahydrofuran / 15 h / 60 °C

6: hydrazine hydrate / ethanol / 2.5 h / 0 - 80 °C

7: triethylamine / dichloromethane / 15 h / 0 - 20 °C

With dmap; potassium permanganate; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1444001-41-5
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-2-oxopiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / dimethyl sulfoxide / 15 h / 55 °C

2: N-benzyl-N,N,N-triethylammonium chloride; potassium permanganate / dichloromethane / 84 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr

4: ethanol / 15 h / Reflux

5: dmap / tetrahydrofuran / 15 h / 60 °C

6: hydrazine hydrate / ethanol / 2.5 h / 0 - 80 °C

7: triethylamine / dichloromethane / 15 h / 0 - 20 °C

With dmap; potassium permanganate; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2013.03.056