Technology Process of 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile
There total 1 articles about 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 7h;
Heating;
DOI:10.1021/jo0344081
- Guidance literature:
-
With
trichlorophosphate;
at 150 ℃;
for 9h;
DOI:10.1021/jo0344081
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 54 percent / phosphorus oxychloride / 9 h / 150 °C
2.1: 62 percent / diisobutylaluminum hydride / CH2Cl2; toluene / -78 - 20 °C
3.1: Mg / tetrahydrofuran
3.2: 73 percent / tetrahydrofuran / -78 - 0 °C
4.1: 78 percent / PCC / CH2Cl2 / 1.5 h / 20 °C
5.1: 85 percent / sodium periodate / methanol; H2O / 0 - 20 °C
6.1: 37 percent / heptafluorobutyric anhydride; p-toluenesulfonic acid / toluene / 1.17 h / Heating
7.1: 94 percent / NaIO4 / RuCl3*xH2O / H2O; acetonitrile; CCl4 / 2 h / 20 °C
8.1: 77 percent / DBU / toluene / 1 h / Heating
9.1: 89 percent / diethyl ether / 0 - 20 °C
10.1: 90 percent / DIBAL-H / CH2Cl2; toluene / -78 - 0 °C
With
sodium periodate; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; heptafluorobutyric anhydride; trichlorophosphate;
ruthenium trichloride;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; toluene; acetonitrile;
3.2: Grignard reaction / 6.1: sequential Pummerer-Diels-Alder reaction;
DOI:10.1021/jo0344081
