2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

Base Information

Chemical Name:2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile
CAS No.:607708-11-2
Molecular Formula:C₁₃H₁₀N₂O₂S
Molecular Weight:258.301
Hs Code.:

Synonyms:2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

Suppliers and Price of 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

There total 1 articles about 2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 25907-38-4
ethyl 4-(phenylthio)-acetoacetate

: 107-91-5
cyanoacetic acid amide

: 607708-11-2
2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

Guidance literature:: With potassium hydroxide; In methanol; for 7h; Heating;
DOI:10.1021/jo0344081

Reference yield: 54.0%

: 607708-11-2
2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

: 441052-90-0
2,6-dichloro-4-[(phenylthio)methyl]nicotinonitrile

Guidance literature:: With trichlorophosphate; at 150 ℃; for 9h;
DOI:10.1021/jo0344081

Reference yield:

: 607708-11-2
2,6-dihydroxy-4-[(phenylthio)methyl]nicotinonitrile

: 5,7-dichloro-9-methoxy-4-(4-methylphenyl)furo[3,4-g]isoquinolin-3(1H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 54 percent / phosphorus oxychloride / 9 h / 150 °C

2.1: 62 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / -78 - 20 °C

3.1: Mg / tetrahydrofuran

3.2: 73 percent / tetrahydrofuran / -78 - 0 °C

4.1: 78 percent / PCC / CH₂Cl₂ / 1.5 h / 20 °C

5.1: 85 percent / sodium periodate / methanol; H₂O / 0 - 20 °C

6.1: 37 percent / heptafluorobutyric anhydride; p-toluenesulfonic acid / toluene / 1.17 h / Heating

7.1: 94 percent / NaIO₄ / RuCl₃*xH₂O / H₂O; acetonitrile; CCl₄ / 2 h / 20 °C

8.1: 77 percent / DBU / toluene / 1 h / Heating

9.1: 89 percent / diethyl ether / 0 - 20 °C

10.1: 90 percent / DIBAL-H / CH₂Cl₂; toluene / -78 - 0 °C

With sodium periodate; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; heptafluorobutyric anhydride; trichlorophosphate; ruthenium trichloride; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; toluene; acetonitrile; 3.2: Grignard reaction / 6.1: sequential Pummerer-Diels-Alder reaction;
DOI:10.1021/jo0344081