Technology Process of N-[5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl]-1,1-diphenylmethanimine
There total 9 articles about N-[5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl]-1,1-diphenylmethanimine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
toluene;
for 6h;
Reflux;
DOI:10.1016/j.bioorg.2020.104130
- Guidance literature:
-
6-bromo-2,4,5-trimethylpyridine-3-ol; benzyl chloride;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Benzophenone imine;
With
tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate;
In
toluene;
for 12h;
Reflux;
DOI:10.1080/14756366.2019.1677637
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C
2: zinc; acetic acid / 3 h / Reflux
3: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 3 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
5: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 12 h / Reflux
With
tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; N,N-dimethyl-formamide; sodium t-butanolate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
5: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2014.03.045
