N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

Base Information

Chemical Name:N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride
CAS No.:1378039-43-0
Molecular Formula:C₁₆H₁₁ClFN₇*ClH
Molecular Weight:392.223
Hs Code.:

Synonyms:N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

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Chemical Property of N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

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Technology Process of N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

There total 9 articles about N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1378039-42-9
{6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

: 1378039-43-0
N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 50 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 114077-82-6
4-chloronicotinaldehyde

: 1378039-43-0
N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h

2: triethylamine; titanium tetrachloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3: toluene / 18 h / 105 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

5: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 4.75 h / 0 - 20 °C

6: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 1.5 h / 60 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

8: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere; Sealed tube

9: hydrogenchloride / isopropyl alcohol / 18 h / 50 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; potassium phosphate; sodium azide; titanium tetrachloride; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 1378039-40-7
[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-carbamic acid tert-butyl ester

: 1378039-43-0
N-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3: hydrogenchloride / isopropyl alcohol / 18 h / 50 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; isopropyl alcohol;