114077-82-6

Basic information

• Product Name: 4-Chloropyridine-3-carboxaldehyde
• Synonyms: 4-CHLOROPYRIDINE-3-CARBOXALDEHYDE;4-CHLORO-3-FORMYLPYRIDINE;3-Pyridinecarboxaldehyde,4-chloro-(9CI);4-chloro-3-pyridincarboxaldehyde;4-Chloronicotinaldehyde;4-Chloro-3-pyridinecarboxaldehyde;4-chloropyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 4-chloro-
• CAS NO: 114077-82-6
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Product Categories: PYRIDINE;Building Blocks;Pyridines;pyridine series;Heterocycle-Pyridine series
• Mol File: 114077-82-6.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 228.753 °C at 760 mmHg
• Flash Point: 92.147 °C
• Appearance: /
• Density: 1.332 g/cm³
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.89±0.10(Predicted)
• CAS DataBase Reference: 4-Chloropyridine-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-3-carboxaldehyde(114077-82-6)
• EPA Substance Registry System: 4-Chloropyridine-3-carboxaldehyde(114077-82-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 114077-82-6(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder

InChI:InChI=1/C6H4ClNO/c7-6-1-2-8-3-5(6)4-9/h1-4H

Upstream product

• 626-61-9 4-Chloropyridine 
• 109-94-4 formic acid ethyl ester 
• 69045-79-0 2-choro-5-iodopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 10177-29-4 4-chloronicotinic acid 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 109-72-8 n-butyllithium 
• 2591-86-8 N-Formylpiperidine 
• 189449-41-0 4-chloro-3-(hydroxymethyl)pyridine 

Downstream Products

• 662150-30-3 4-{[4-(methylsulfanyl)phenyl]sulfanyl}nicotinaldehyde 
• 82257-16-7 formyl-3 methylthio-4 pyridine 
• 947371-37-1 4-chloro-3-difluoromethylpyridine 
• 471909-43-0 4-chloro-pyridine-3-carbaldehyde oxime 
• 1021950-19-5 tert-butyl N-[4-[(3-formyl-4-pyridyl)oxy]phenyl]carbamate 
• 1426165-41-4 [(2-chloropyridine-3-yl)methyl](triphenyl)phosphonium bromide 

Relevant articles and documents

Aromatizing olefin metathesis by ligand isolation inside a metal- organic framework

The aromatizing ring-closing metathesis has been shown to take place inside an extended porous framework. Employing a combination of solvent-assisted linker exchange and postsynthesis modification using olefin metathesis, the noninterpenetrated SALEM-14 was formed and converted catalytically into PAH-MOF-1 with polycyclic aromatic hydrocarbon (PAH) pillars. The metal-organic framework in SALEM-14 prevents "intermolecular" olefin metathesis from occurring between the pillars in the presence of the first generation Hoveyda-Grubbs catalyst, while favoring the production of a PAH, which can be released from the framework under acidic conditions in dimethylsulfoxide.

NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF

The present disclosure relates to a novel substituted pyrazole derivative having an effect of inhibiting serine/threonine kinase activity targeting receptor ALK5 of TGF-β, and a pharmaceutical composition including the compound of the present disclosure as an active ingredient may be useful in preventing and/or treating cancers, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, pulmonary diseases, cardiovascular diseases or metabolic diseases, or other diseases associated with a decrease in TGF family signaling activity.

A 3 - aldehyde -4 - chloro pyridine green preparation method

The invention discloses a 3 - aldehyde - 4 - chloro pyridine green preparation method, which belongs to the technical field of organic synthesis. Technical proposal of the invention points are: to pyridine as raw materials, the selective chlorination, after the adoption of the salt in the solvent impurities and product of different solubility, can be recrystallized separation, to obtain 4 - chloro pyridine pure product, finally is then subjected to an N, N - dimethyl formamide substitution reaction to obtain the 3 - aldehyde - 4 - chloro pyridine. The invention compared with the prior art has the following advantages: the invention synthetic method is simple, cheap price of raw materials, and is favorable for industrial production.

HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF

Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.