(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

Base Information

Chemical Name:(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide
CAS No.:1456505-12-6
Molecular Formula:C₂₈H₂₃N₃O₃
Molecular Weight:449.509
Hs Code.:

Synonyms:(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

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Chemical Property of (R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

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Technology Process of (R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

There total 5 articles about (R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1203050-38-7
4-iodo-N-(quinolin-8-yl)benzamide

: 1456507-20-2
8-phenyl-5-oxa-7-azaspiro[3.4]octan-6-one

: 1456505-12-6
(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 103-82-2
phenylacetic acid

: 1456505-12-6
(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0 - 20 °C

1.2: -78 - 20 °C

2.1: diphenylphosphoranyl azide; triethylamine / toluene / 12 h / 120 °C

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diphenylphosphoranyl azide; caesium carbonate; triethylamine; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; toluene;

Reference yield:

: 5463-97-8
2-(1-hydroxycyclobutyl)-2-phenylacetic acid

: 1456505-12-6
(R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 12 h / 120 °C

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diphenylphosphoranyl azide; caesium carbonate; triethylamine; XPhos; In 1,4-dioxane; toluene;