5463-97-8

Usage

Uses

Used in Pharmaceutical Industry:
(1-hydroxycyclobutyl)(phenyl)acetic acid is used as a COX inhibitor for its anti-inflammatory properties. It is particularly valuable for the development of new medications aimed at relieving pain and reducing inflammation, as COX inhibitors are commonly used for these purposes.
Used in Drug Discovery and Development:
Due to its specific structure and properties, (1-hydroxycyclobutyl)(phenyl)acetic acid serves as a target for further research in drug discovery and development. Its potential as a COX inhibitor and anti-inflammatory agent makes it a valuable compound for exploring novel therapeutic approaches and improving existing treatments for various inflammatory conditions.

Upstream product

• 103-82-2 phenylacetic acid 
• 1191-95-3 cyclobutanone 
• 95777-19-8 phenylacetic acid magnesium enediolate 

Downstream Products

• 1456507-20-2 8-phenyl-5-oxa-7-azaspiro[3.4]octan-6-one 
• 1456505-12-6 (R+S) 4-(6-oxo-8-phenyl-5-oxa-7-azaspiro[3.4]octan-7-yl)-N-(quinolin-8-yl)benzamide 
• 40297-26-5 (±)-2-(4-chlorophenyl)cyclopentan-1-one 
• 55930-34-2 N-Hydroxy-2-(1-hydroxy-cyclobutyl)-2-phenyl-acetamide 

Relevant academic research and scientific papers

OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Kinetics and Mechanism of the Ivanov Reaction: Reaction of Aldehydes and Ketones with Phenylacetic Acit Magnesium Enediolate

Stopped-flow kinetics of the reaction between aldehydes or ketones and the magnesium enediolate of phenylacetic acid in THF are second order at enediolate concentrations -3 M.At concentrations of 10-3 - 3*10-2 M, the formation of a bis(enediolate) requires a more complex kinetic equation.Second-order rate constans are reported for the reaction of the enediolate with a number of aldehydes and ketones at 25 deg C.Entropies of activation for cyclohexanone, benzaldehyde, 2-methylpropanal, and 2,2-dimethylpropanal are positive, and enthalpy-entropy compensation is observed.Ef fects of cycloalkanone ring size and benzaldehyde substituents are small and are ascribable to a transition state with a very small C-C bond order.A two-step mechanism is proposed, with preequilibrium formation of a coordination intermediate which, in some cases, is accompanied by a change in the magnesium coordination number.Effects of alkyl groups on aldehyde and ketone reactivity stem mainly from steric desolvation.