2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

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Chemical Name:2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid
CAS No.:1476068-49-1
Molecular Formula:C₄₀H₅₂N₄O₆
Molecular Weight:684.876
Hs Code.:

Synonyms:2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

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Chemical Property of 2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

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Technology Process of 2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

There total 7 articles about 2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 111-68-2
1-Heptylamine

: 1476064-46-6
2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 1476068-49-1
2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

Guidance literature:: With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 140 ℃; for 0.5h; Inert atmosphere; Sealed tube; Microwave irradiation;
DOI:10.1055/s-0033-1338497

Reference yield:

: 643-28-7
2-isopropylaniline

: 1476068-49-1
2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

3.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

4.1: triethylamine; isobutyl chloroformate / acetonitrile / 0.42 h / 20 °C / Inert atmosphere

4.2: 2 h / 60 °C / Inert atmosphere; Microwave irradiation

5.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); ammonium acetate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; sodium nitrite; isobutyl chloroformate; In 1,4-dioxane; water; acetonitrile;
DOI:10.1055/s-0033-1338497

Reference yield:

: 50294-51-4
2-(amino)tricyclo[3.3.1.13,7]decane-2-carboxylic acid hydrochloride

: 1476068-49-1
2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

2.1: triethylamine; isobutyl chloroformate / acetonitrile / 0.42 h / 20 °C / Inert atmosphere

2.2: 2 h / 60 °C / Inert atmosphere; Microwave irradiation

3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; isobutyl chloroformate; In 1,4-dioxane; acetonitrile;
DOI:10.1055/s-0033-1338497