2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

Base Information

• Chemical Name: 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid
• CAS No.: 1476064-46-6
• Molecular Formula: C₃₂H₃₆BrN₃O₅
• Molecular Weight: 622.559
• Mol file: 1476064-46-6.mol

Synonyms:2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

Chemical Property of 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

There total 5 articles about 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1279881-34-3) + C14H25NO2Si → 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid (1476064-46-6)

Guidance literature:

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In acetonitrile; at 20 ℃; for 0.416667h; Inert atmosphere;

C₁₄H₂₅NO₂Si; In acetonitrile; at 60 ℃; for 2h; Inert atmosphere; Microwave irradiation;

With hydrogenchloride; water; In acetonitrile;

DOI:10.1055/s-0033-1338497

Reference yield:

2-(amino)tricyclo[3.3.1.13,7]decane-2-carboxylic acid hydrochloride (50294-51-4) → 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid (1476064-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

2.1: triethylamine; isobutyl chloroformate / acetonitrile / 0.42 h / 20 °C / Inert atmosphere

2.2: 2 h / 60 °C / Inert atmosphere; Microwave irradiation

With triethylamine; isobutyl chloroformate; In acetonitrile;

DOI:10.1055/s-0033-1338497

Reference yield:

2-isopropylaniline (643-28-7) → 2-({[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid (1476064-46-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

3.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

4.1: triethylamine; isobutyl chloroformate / acetonitrile / 0.42 h / 20 °C / Inert atmosphere

4.2: 2 h / 60 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; ammonium acetate; water; triethylamine; potassium hydroxide; sodium nitrite; isobutyl chloroformate; In 1,4-dioxane; water; acetonitrile;

DOI:10.1055/s-0033-1338497

upstream raw materials:

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

2-(amino)tricyclo[3.3.1.13,7]decane-2-carboxylic acid hydrochloride

2-isopropylaniline

4-bromo-2-isopropyl-aniline

Downstream raw materials:

2-{[(5-(2,6-dimethoxyphenyl)-1-{4-[(heptylamino)carbonyl]-2-isopropylphenyl}-1H-pyrazol-3-yl)carbonyl]amino}adamantane-2-carboxylic acid

2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-(dimethylamino)propyl]amino}carbonyl)-2-isopropylphenyl]-1H-pyrazol-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-(dimethylamino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1H-pyrazol-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

2-({[5-(2,6-dimethoxyphenyl)-1-(2-isopropyl-4-{[methyl(3-{methyl[6-(triisopropylsilyl)hex-5-yn-1-yl]amino}propyl)amino]carbonyl}phenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid