(10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol

Base Information

• Chemical Name: (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol
• CAS No.: 1356008-91-7
• Molecular Formula: C₂₆H₂₆FN₇O₂
• Molecular Weight: 487.537

Synonyms:(10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol

Chemical Property of (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol

There total 9 articles about (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol trifluoroacetate (1356008-90-6) → (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-91-7) + (10R,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-70-2) + (10S,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-92-8) + (10R,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-69-9)

Guidance literature:

With Chiralpak AD-H; In methanol; carbon dioxide; at 35 ℃; under 112511 Torr; Resolution of racemate;

Reference yield:

cyclopentanone (120-92-3) → (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-91-7) + (10R,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-70-2) + (10S,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-92-8) + (10R,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-69-9)

Guidance literature:

Multi-step reaction with 9 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

7: ammonium chloride; iron / water; methanol / 1 h / 80 °C

8: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 100 °C

9: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; caesium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; carbon dioxide; water; acetonitrile;

Reference yield:

4-flourophenylmagnesium bromide (352-13-6) → (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-91-7) + (10R,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-70-2) + (10S,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356008-92-8) + (10R,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol (1356010-69-9)

Guidance literature:

Multi-step reaction with 9 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

7: ammonium chloride; iron / water; methanol / 1 h / 80 °C

8: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 100 °C

9: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; caesium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; carbon dioxide; water; acetonitrile;

upstream raw materials:

cyclopentanone

4-flourophenylmagnesium bromide

1-cyclopent-1-enyl 4-fluorobenzene

(±)-2-(4-fluorophenyl)cyclopentan-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1356008-91-7 (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send