tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate
• CAS No.: 1393593-22-0
• Molecular Formula: C₂₄H₃₂ClNO₂
• Molecular Weight: 401.977

Synonyms:tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property of tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property:

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Technology Process of tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 1 articles about tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl cinnamate (14990-09-1) + (R)-N-(3′-chloropropyl)-N-(α-methylbenzyl)amine (1393593-20-8) → tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-22-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jo3012732

Reference yield: 86.0%

tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-22-0) + 1-amino-2-propene (107-11-9,30551-89-4) → tert-butyl (3S, αR)-3-[N-( 3'-(N'-allylamino)propyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-27-5)

Guidance literature:

With sodium iodide; at 65 ℃; for 24h;

DOI:10.1021/jo3012732

Reference yield: 79.0%

tert-butyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-22-0) → tert-butyl (3S, αR)-3-[N-( 3'-azidopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-24-2)

Guidance literature:

With sodium azide; sodium iodide; In dimethyl sulfoxide; at 50 ℃; for 48h;

DOI:10.1021/jo3012732

upstream raw materials:

tert-butyl cinnamate

(R)-N-(3′-chloropropyl)-N-(α-methylbenzyl)amine

Downstream raw materials:

tert-butyl (3S, αR)-3-[N-( 3'-azidopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

tert-butyl (3S, αR)-3-[N-( 3'-aminopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

methyl (3S, αR)-3-[N-( 3'-(N'-allylamino)propyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

tert-butyl (3S, αR)-3-[N-( 3'-(N'-allylamino)propyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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