3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

Base Information

Chemical Name:3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride
CAS No.:1398706-97-2
Molecular Formula:C₁₆H₁₄Cl₂FNO*ClH
Molecular Weight:362.659
Hs Code.:

Synonyms:3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

Chemical Property:

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Technology Process of 3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

There total 3 articles about 3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1398705-44-6
C₂₁H₂₂Cl₂FNO₃

: 1398706-97-2
3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

Guidance literature:: With hydrogenchloride; water; In methanol; at 60 ℃; for 12h;
DOI:10.1021/jm3008294

Reference yield: 86.0%

: 1398706-97-2
3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; at 60 ℃; for 24h;

Reference yield:

: 1398705-03-7
tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

: 1398706-97-2
3-((3,4-dichlorophenyl)(2-fluorophenoxy)methyl)azetidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

2: hydrogenchloride; water / methanol / 12 h / 60 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement;
DOI:10.1021/jm3008294