Technology Process of tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate
There total 4 articles about tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 1h;
- Guidance literature:
-
tert-butyl 3-formylazetidine-1-carboxylate; 3,4-dichlorophenylmagnesium bromide;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
With
ammonium chloride;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
3.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
With
oxalyl dichloride; dimethylsulfide borane complex; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Grignard Reaction;
DOI:10.1021/jm3008294