tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

Base Information

Chemical Name:tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate
CAS No.:1398705-03-7
Molecular Formula:C₁₅H₁₉Cl₂NO₃
Molecular Weight:332.227
Hs Code.:

Synonyms:tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

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Chemical Property of tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

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Technology Process of tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

There total 4 articles about tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

: 1398705-03-7
tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 1h;

Reference yield: 68.0%

: 177947-96-5
tert-butyl 3-formylazetidine-1-carboxylate

: 79175-35-2
3,4-dichlorophenylmagnesium bromide

: 1398705-03-7
tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

Guidance literature:: tert-butyl 3-formylazetidine-1-carboxylate; 3,4-dichlorophenylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 3h;

With ammonium chloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

: 142253-55-2
1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

: 1398705-03-7
tertiary butyl 3-((3,4-dichlorophenyl)(hydroxy)methyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With oxalyl dichloride; dimethylsulfide borane complex; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Grignard Reaction;
DOI:10.1021/jm3008294