(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:121148-03-6
Molecular Formula:C₁₂H₁₆N₂O₄S
Molecular Weight:284.336
Hs Code.:

Synonyms:(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

There total 9 articles about (2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121147-99-7
methyl (2R,4R)-4-azido-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

: 121148-03-6
(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; under 2280 Torr;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

: 121148-03-6
(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

3: 71.1 percent / dimethylsulfoxide / 90 °C

4: 82.5 percent / potassium carbonate / methanol / 1 h / 20 °C

5: 100 percent / triethylamine / CH₂Cl₂ / 4 h / 0 - 5 °C

6: 97 percent / sodium azide / dimethylsulfoxide / 90 °C

7: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

With sodium azide; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 121148-03-6
(2R,4R)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

3: 71.1 percent / dimethylsulfoxide / 90 °C

4: 82.5 percent / potassium carbonate / methanol / 1 h / 20 °C

5: 100 percent / triethylamine / CH₂Cl₂ / 4 h / 0 - 5 °C

6: 97 percent / sodium azide / dimethylsulfoxide / 90 °C

7: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

With sodium azide; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2