5-BENZYL-2-HYDROXY-BENZALDEHYDE

Base Information

• Chemical Name: 5-BENZYL-2-HYDROXY-BENZALDEHYDE
• CAS No.: 72375-01-0
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• Mol file: 72375-01-0.mol

Synonyms:5-benzyl-2-hydroxybenzaldehyde

Chemical Property of 5-BENZYL-2-HYDROXY-BENZALDEHYDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-benzyl-2-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-BENZYL-2-HYDROXY-BENZALDEHYDE

There total 7 articles about 5-BENZYL-2-HYDROXY-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(phenylmethoxy)benzaldehyde (5896-17-3) → 3-benzyl-2-hydroxybenzaldehyde (131628-72-3) + 5-benzyl-2-hydroxybenzaldehyde (72375-01-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 96h; Reflux; Inert atmosphere;

DOI:10.1055/s-0029-1217064

Reference yield: 64.0%

benzylzinc chloride-lithium chloride complex + 5-bromosalicyclaldehyde (1761-61-1) → 5-benzyl-2-hydroxybenzaldehyde (72375-01-0)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1248/cpb.c19-00634

Reference yield: 11.0%

2-(phenylmethoxy)benzaldehyde (5896-17-3) → 3-benzyl-2-hydroxybenzaldehyde (131628-72-3) + 2-methyl-benzyl alcohol (89-95-2) + 5-benzyl-2-hydroxybenzaldehyde (72375-01-0)

Guidance literature:

With amberlyst-15; In toluene; at 110 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1021/jo052337v

upstream raw materials:

p-benzylphenol

chloroform

benzyl chloride

salicylaldehyde

Downstream raw materials:

bis-[4-(5-benzyl-2-hydroxy-benzylidenamino)-phenyl]-sulfoxide

5-benzyl-3-chlorosalicylaldehyde

5-benzyl-3-bromosalicylaldehyde

3-acetyl-6-benzyl-coumarin