dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Base Information

Chemical Name:dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate
CAS No.:1360583-83-0
Molecular Formula:C₂₃H₂₀N₂O₄
Molecular Weight:388.423
Hs Code.:

Synonyms:dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

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Chemical Property of dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

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Technology Process of dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

There total 3 articles about dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1360583-77-2
dimethyl 2-[(1-benzyl-5-cyano-1H-indol-3-yl)methylene]malonate

: 1360583-83-0
dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Guidance literature:: With trimethylsulfoxonium iodide; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1002/chem.201101687

Reference yield:

: 17380-18-6
3-formyl-1H-indole-5-carbonitrile

: 1360583-83-0
dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; potassium hydroxide / 0.75 h

1.2: 20 °C

2.1: piperidine; acetic acid / toluene / 4 h / Reflux

3.1: trimethylsulfoxonium iodide; sodium hydride / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

With piperidine; trimethylsulfoxonium iodide; sodium hydride; acetic acid; dimethyl sulfoxide; potassium hydroxide; In dimethyl sulfoxide; toluene;
DOI:10.1002/chem.201101687

Reference yield:

: 1360583-74-9
1-benzyl-5-cyano-1H-indole-3-carbaldehyde

: 108-59-8
malonic acid dimethyl ester

: 1360583-83-0
dimethyl 2-(1-benzyl-5-cyano-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / toluene / 4 h / Reflux

2: trimethylsulfoxonium iodide; sodium hydride / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

With piperidine; trimethylsulfoxonium iodide; sodium hydride; acetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1002/chem.201101687