Technology Process of benzyl 3-((2R,3S)-3-acetyloxiran-2-yl)propanoate
There total 3 articles about benzyl 3-((2R,3S)-3-acetyloxiran-2-yl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Cumene hydroperoxide; (S)-N-tert-butyl-3-phenylpropane-1,2-diamine; trifluoroacetic acid;
In
toluene;
at 30 ℃;
for 24h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1002/adsc.201100230
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 12 h / 20 °C
2: (S)-N-tert-butyl-3-phenylpropane-1,2-diamine; Cumene hydroperoxide; trifluoroacetic acid / toluene / 24 h / 30 °C
With
Cumene hydroperoxide; (S)-N-tert-butyl-3-phenylpropane-1,2-diamine; trifluoroacetic acid;
In
tetrahydrofuran; toluene;
DOI:10.1002/adsc.201100230
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
1.2: 0.5 h / -78 - 20 °C
2.1: tetrahydrofuran / 12 h / 20 °C
3.1: (S)-N-tert-butyl-3-phenylpropane-1,2-diamine; Cumene hydroperoxide; trifluoroacetic acid / toluene / 24 h / 30 °C
With
oxalyl dichloride; Cumene hydroperoxide; (S)-N-tert-butyl-3-phenylpropane-1,2-diamine; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1002/adsc.201100230
