(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate
CAS No.:1402883-91-3
Molecular Formula:C₂₆H₃₂BrN₃O₇
Molecular Weight:578.46
Hs Code.:

Synonyms:(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Suppliers and Price of (1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

There total 6 articles about (1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₃BrN₃O₃^(1-)*Na⁽¹⁺⁾

: 1402883-91-3
(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3011405

Reference yield:

: 1402883-78-6
(1S,5R)-1-(3-bromophenyl)-3-oxabicyclo[3.1.0]hexan-2-one

: 1402883-91-3
(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

3.2: 20 - 80 °C

4.1: sodium ethanolate / ethanol / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405

Reference yield:

: 1402883-80-0
sodium (1S,2R)-1-(3-bromophenyl)-2-(hydroxymethyl)cyclopropanecarboxylate

: 1402883-91-3
(1S,2R)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 20 °C

2.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

2.2: 20 - 80 °C

3.1: sodium ethanolate / ethanol / 95 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405