dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate

Base Information

• Chemical Name: dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate
• CAS No.: 129082-60-6
• Molecular Formula: C₂₆H₃₂N₆O₉
• Molecular Weight: 572.575
• Mol file: 129082-60-6.mol

Synonyms:dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate

Chemical Property of dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate

There total 3 articles about dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl N-(4-amino-benzoyl)-L-glutamate (52407-60-0) + 2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetaldehyde (118270-99-8) → dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate (129082-60-6)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; for 0.5h; Yield given;

DOI:10.1002/jhet.5570270264

Reference yield:

2,6-diamino-5-(3,3-diethoxyethyl)pyrimidin-4(3H)-one (63026-85-7) → dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate (129082-60-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / pyridine / 120 h / Heating

2: 46 percent / p-toluenesulfonic acid monohydrate / acetone / 48 h

3: sodium cyanoborohydride / acetic acid / 0.5 h

With pyridine; sodium cyanoborohydride; toluene-4-sulfonic acid; In acetic acid; acetone;

DOI:10.1002/jhet.5570270264

Reference yield:

2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetaldehyde diethyl acetal (118270-98-7) → dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate (129082-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / p-toluenesulfonic acid monohydrate / acetone / 48 h

2: sodium cyanoborohydride / acetic acid / 0.5 h

With sodium cyanoborohydride; toluene-4-sulfonic acid; In acetic acid; acetone;

DOI:10.1002/jhet.5570270264

upstream raw materials:

dimethyl N-(4-amino-benzoyl)-L-glutamate

2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetaldehyde

2,6-diamino-5-(3,3-diethoxyethyl)pyrimidin-4(3H)-one

2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetaldehyde diethyl acetal

Downstream raw materials:

N-<4-<2-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamic acid