63026-85-7

Upstream product

• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 50-01-1 guanidine hydrochloride 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 621-62-5 chloroacetaldehyde diethyl acetal 

Downstream Products

• 137281-08-4 N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 129082-60-6 dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate 
• 129082-61-7 dimethyl N<4-<2-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)ethyl-N-methylamino>benzoyl>-L-glutamate 
• 118270-97-6 N<4-<2-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethyl-N-methylamino>benzoyl>-L-glutamic acid 
• 118252-47-4 N-<4-<2-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamic acid 
• 923971-28-2 N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide 

Relevant academic research and scientific papers

Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes

A series of eleven novel 2,6-diamino-5-[(2-substituted phenylamino)ethyl] pyrimidin-4(3H)-one derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) and thymidylate synthase (TS). The synthesis of analogues 2a-f, 3a and 3e

Acyclic Nucleoside Analogs. II. Acyclic Analogs of Guanosine, 7-Deazaguanosine, and 7-Deazaadenosine with a cis-Hydroxypentene Fragment

Condensations of 5-acetoxy-1-bromo-2-pentene with 2-amino-6-chloropurine, 4-chloropyrrolopyrimidine, and 2-amino-4-chloropyrrolopyrimidine sodium salts gave acyclic analogs of guanosine, 7-deazaguanosine, and 7-deazaadenosine.The subsequent deprotection with 0.1 N NaOH or methanol saturated with ammonium yielded the desired nucleoside analogs containing a cis-hydroxypentene fragment and either natural or modified heterocycle. - Keywords: nucleosides; acyclic analogs; pyrrolopyrimidines.