rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

Base Information

Chemical Name:rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid
CAS No.:1352419-33-0
Molecular Formula:C₁₁H₉BrClF₂NO₃
Molecular Weight:356.551
Hs Code.:

Synonyms:rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

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Technology Process of rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

There total 1 articles about rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

: 1352126-43-2
rac-2-amino-2-(5-bromo-2,4-difluoro-phenyl)-propionic acid

: 79-04-9
chloroacetyl chloride

: 1352419-33-0
rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1h; pH=10 - 11;

Reference yield: 65.5%

: 1352419-33-0
rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

: 1352419-34-1
rac-3-(5-bromo-2,4-difluorophenyl)-3-methylmorpholine-2,5-dione

Guidance literature:: With N,N-dimethyl-formamide; at 110 ℃; for 48h;

Reference yield:

: 1352419-33-0
rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

: (RS,RS)-5-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-fluoro-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 48 h / 110 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: ammonia / water; methanol / 28 h / 60 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

With ammonia; diisobutylaluminium hydride; sodium hydrogencarbonate; N,N-dimethyl-formamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water;