C₁₇H₂₀Cl₂N₂O₃

Base Information

• Chemical Name: C₁₇H₂₀Cl₂N₂O₃
• CAS No.: 1430798-56-3
• Molecular Formula: C₁₇H₂₀Cl₂N₂O₃
• Molecular Weight: 371.263
• Mol file: 1430798-56-3.mol

Synonyms:C₁₇H₂₀Cl₂N₂O₃

Chemical Property of C₁₇H₂₀Cl₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₂₀Cl₂N₂O₃

There total 4 articles about C₁₇H₂₀Cl₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-(4,6-dichloro-5-methoxy-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (1221589-79-2) + C5H8INO (1430798-68-7) → C17H20Cl2N2O3 (1430798-56-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 3h; Inert atmosphere; Schlenk technique;

Reference yield:

(4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane) (1221589-81-6) → C17H20Cl2N2O3 (1430798-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Iodine monochloride / dichloromethane / 20 °C / Cooling with ice

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24.08 h / 80 °C / Inert atmosphere; Schlenk technique

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere; Schlenk technique

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; Iodine monochloride; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

2,6-dichloroanisole (1984-65-2) → C17H20Cl2N2O3 (1430798-56-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3.5 h / -78 - -65 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / -75 - -65 °C / Inert atmosphere; Schlenk technique

2.1: Iodine monochloride / dichloromethane / 20 °C / Cooling with ice

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24.08 h / 80 °C / Inert atmosphere; Schlenk technique

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere; Schlenk technique

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; Iodine monochloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

2,2'-(4,6-dichloro-5-methoxy-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

C₅H₈INO

(4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane)

2,6-dichloroanisole

Downstream raw materials:

10-methoxy-1,4,6,9-tetramethyl-1H,9H-pyrido[3,2-g]quinoline-2,8-dione