Technology Process of (4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane)
There total 1 articles about (4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C10H14Cl2OSi;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -75 - -65 ℃;
for 4h;
Inert atmosphere;
chloro-trimethyl-silane;
In
tetrahydrofuran; hexane;
at -75 - -65 ℃;
for 14h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ja100610m
- Guidance literature:
-
With
Iodine monochloride;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/ja100610m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Iodine monochloride / dichloromethane / 20 °C / Cooling with ice
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24.08 h / 80 °C / Inert atmosphere; Schlenk technique
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 3 h / 87 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; Iodine monochloride; potassium carbonate;
In
1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;
