Technology Process of 7-[4-(1-aminocyclobutyl)phenyl]-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthylidin-1-amine
There total 7 articles about 7-[4-(1-aminocyclobutyl)phenyl]-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthylidin-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; water;
In
methanol;
at 80 ℃;
for 0.0833333h;
Miocrowave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
2.2: -78 - 0 °C
2.3: 0 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 - 120 °C / Inert atmosphere
4.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave irradiation
5.1: sodium carbonate / ethanol; dichloromethane / 0.5 h / 20 °C
6.1: hydrogenchloride; water / methanol / 0.08 h / 80 °C / Miocrowave irradiation
With
hydrogenchloride; water; isopropylmagnesium chloride; sodium carbonate; potassium carbonate; hydrazine;
bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 18 h / 60 °C / Inert atmosphere
2.1: bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
3.2: -78 - 0 °C
3.3: 0 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 - 120 °C / Inert atmosphere
5.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave irradiation
6.1: sodium carbonate / ethanol; dichloromethane / 0.5 h / 20 °C
7.1: hydrogenchloride; water / methanol / 0.08 h / 80 °C / Miocrowave irradiation
With
hydrogenchloride; sodium azide; tetrabutylammomium bromide; water; isopropylmagnesium chloride; zinc trifluoromethanesulfonate; sodium carbonate; potassium carbonate; hydrazine;
bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
1.1: Curtius Rearrangement;
