4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

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Chemical Name:4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one
CAS No.:1426699-37-7
Molecular Formula:C₂₁H₂₄ClN₅O₂
Molecular Weight:413.907
Hs Code.:

Synonyms:4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

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Chemical Property of 4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

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Technology Process of 4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

There total 7 articles about 4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1426699-36-6
benzyl 3-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-5-chloro-2-ethoxy-6-methylphenyl}azetidine-1-carboxylate

: 1426699-37-7
4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: benzyl 3-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-5-chloro-2-ethoxy-6-methylphenyl}azetidine-1-carboxylate; With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; water; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

: 1382996-91-9
1-(5-chloro-2-ethoxy-3-iodo-4-methylphenyl)ethan-1-one

: 1426699-37-7
4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

1.2: 70 °C

2.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

4.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

5.1: hydrogen; 5%-palladium/activated carbon; hydrogenchloride / water; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; 5%-palladium/activated carbon; hydrogen; caesium carbonate; ethylene dibromide; N,N-dimethyl-formamide; potassium iodide; zinc; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1382996-92-0
benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

: 1426699-37-7
4-amino-8-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

3: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

4: hydrogen; 5%-palladium/activated carbon; hydrogenchloride / water; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; 1,3,5-trichloro-2,4,6-triazine; 5%-palladium/activated carbon; hydrogen; caesium carbonate; N,N-dimethyl-formamide; potassium iodide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;