benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate
CAS No.:1382996-92-0
Molecular Formula:C₂₂H₂₄ClNO₄
Molecular Weight:401.89
Hs Code.:

Synonyms:benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

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Chemical Property of benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

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Technology Process of benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

There total 2 articles about benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382996-92-0
benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / acetic acid / 3.5 h / 60 - 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

3.2: 70 °C

With N-iodo-succinimide; chloro-trimethyl-silane; potassium carbonate; ethylene dibromide; zinc; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382996-92-0
benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

2.2: 70 °C

With chloro-trimethyl-silane; potassium carbonate; ethylene dibromide; zinc; In N,N-dimethyl-formamide;

Reference yield: 93.0%

: 1382996-92-0
benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate

: 1382996-93-1
benzyl 3-[3-(1-aminoethyl)-5-chloro-2-ethoxy-6-methylphenyl]azetidine-1-carboxylate

Guidance literature:: benzyl 3-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)azetidine-1-carboxylate; With titanium(IV) tetraethanolate; ammonia; In ethanol; at 0 - 60 ℃; Inert atmosphere;

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 1h;