Technology Process of 4-(phenylthio)-1-tosyl-3,5,8,8a-tetrahydroquinolin-2-one
There total 3 articles about 4-(phenylthio)-1-tosyl-3,5,8,8a-tetrahydroquinolin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; hydroquinone;
In
para-xylene; acetonitrile;
for 5h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.tet.2010.11.096
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C
2: sodium hydrogencarbonate; hydroquinone / para-xylene; acetonitrile / 5 h / Inert atmosphere; Reflux
With
Grubbs catalyst first generation; sodium hydrogencarbonate; hydroquinone;
In
dichloromethane; para-xylene; acetonitrile;
2: aza-Diels-Alder reaction;
DOI:10.1016/j.tet.2010.11.096
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C
3.1: sodium hydrogencarbonate; hydroquinone / para-xylene; acetonitrile / 5 h / Inert atmosphere; Reflux
With
Grubbs catalyst first generation; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydrogencarbonate; hydroquinone;
In
tetrahydrofuran; hexane; dichloromethane; para-xylene; acetonitrile;
3.1: aza-Diels-Alder reaction;
DOI:10.1016/j.tet.2010.11.096
