Technology Process of 2,3-diallyl-4-(phenylthio)-3-sulfolene
There total 1 articles about 2,3-diallyl-4-(phenylthio)-3-sulfolene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-allyl-4-(phenylthio)-3-sulfolene;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.666667h;
Inert atmosphere;
allyl bromide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.tet.2010.11.096
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1016/j.tet.2010.11.096
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C
2.1: sodium hydrogencarbonate; hydroquinone / para-xylene; acetonitrile / 5 h / Inert atmosphere; Reflux
3.1: triethylamine / ethyl acetate / 24 h / 110 °C
4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / Reflux
5.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere
5.2: -78 - 20 °C / Inert atmosphere
With
Grubbs catalyst first generation; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; triethylamine; hydroquinone;
In
tetrahydrofuran; hexane; dichloromethane; para-xylene; ethyl acetate; toluene; acetonitrile;
2.1: aza-Diels-Alder reaction;
DOI:10.1016/j.tet.2010.11.096
